| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Ghostbusters: Afterlife (2021) | £4,314,263 | £4,314,263 | £4,314,263 | new | 1 |
| 2 (1) |  | Eternals (2021) | £1,217,624 | £2,255,081 | £12,826,256 | -58% | 3 |
| 3 (2) |  | No Time To Die (2021) | £940,075 | £1,771,215 | £94,489,174 | -40% | 8 |
| 4 (3) |  | Dune (2021) | £634,843 | £1,243,242 | £20,185,469 | -46% | 5 |
| 5 (new) |  | King Richard (2021) | £570,316 | £570,316 | £570,316 | new | 1 |
| 6 (5) |  | The Boss Baby 2: Family Business (2021) | £355,156 | £409,205 | £6,886,404 | -38% | 5 |
| 7 (4) |  | Spencer (2021) | £304,535 | £830,189 | £2,362,607 | -56% | 3 |
| 8 (6) |  | Venom: Let There Be Carnage (2021) | £280,578 | £506,122 | £17,597,588 | -46% | 6 |
| 9 (8) |  | Ron's Gone Wrong (2021) | £182,390 | £204,954 | £4,477,761 | -34% | 6 |
| 10 (7) |  | The Addams Family 2 (2021) | £173,458 | £205,796 | £10,113,167 | -48% | 7 |
| 11 (9) |  | The French Dispatch of the Liberty, Kansas Evening Sun (2021) | £164,031 | £342,396 | £3,735,517 | -39% | 5 |
| 12 (new) | | Petite Maman (2021) | £97,321 | £97,321 | £97,321 | new | 1 |
| 13 (10) |  | Last Night In Soho (2021) | £97,109 | £228,800 | £2,149,609 | -46% | 4 |
| 14 (new) |  | Pitbull (2021) | £95,042 | £95,042 | £95,042 | new | 1 |
| 15 (11) |  | Mothering Sunday (2021) | £55,476 | £186,821 | £343,761 | -65% | 2 |