| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Arrival (2016) | £2,924,059 | £2,924,059 | £2,924,059 | new | 1 |
| 2 (1) |  | Doctor Strange () | £2,357,258 | £3,865,972 | £19,596,167 | -32% | 3 |
| 3 (2) |  | Trolls () | £1,820,578 | £2,134,552 | £19,327,276 | -9% | 4 |
| 4 (3) |  | The Accountant () | £1,020,899 | £1,998,418 | £3,622,284 | -37% | 2 |
| 5 (4) |  | A Street Cat Named Bob () | £864,653 | £1,623,546 | £2,609,103 | -12% | 2 |
| 6 (5) |  | Nocturnal Animals (2016) | £617,071 | £1,093,504 | £1,848,931 | -18% | 2 |
| 7 (7) |  | The Girl On the Train (2016) | £477,110 | £931,348 | £22,897,010 | -24% | 6 |
| 8 (9) |  | Storks (2016) | £343,898 | £378,178 | £6,249,343 | -6% | 5 |
| 9 (8) |  | Jack Reacher Never Go Back (2016) | £332,422 | £674,871 | £7,627,482 | -42% | 4 |
| 10 (6) |  | The Light Between Ocean's () | £226,094 | £652,150 | £1,385,571 | -69% | 2 |
| 11 (10) |  | Bridget Jones's Baby () | £202,196 | £462,705 | £47,534,721 | -39% | 9 |
| 12 (13) |  | Miss Peregrines Home For Peculiar Children () | £173,441 | £209,916 | £12,160,991 | -25% | 7 |
| 13 (11) |  | I, Daniel Blake (2016) | £173,174 | £472,274 | £2,542,434 | -47% | 4 |
| 14 (new) | | Chaar Sahibzaade 2 Rise of Banda Singh Bahadur () | £132,852 | £132,852 | £132,852 | new | 1 |
| 15 (14) |  | Inferno (2016) | £122,752 | £248,770 | £8,133,444 | -43% | 5 |
| 16 (new) |  | American Pastoral (2016) | £56,832 | £56,832 | £56,832 | new | 1 |
| 17 (18) |  | The BFG () | £32,707 | £34,013 | £30,514,629 | 34% | 17 |
| 18 (new) | | Rock On 2 () | £27,020 | £27,020 | £27,020 | new | 1 |
| 19 (new) | | The Innocents (2016) | £24,133 | £24,133 | £24,133 | new | 1 |
| 20 (30) |  | Miss Saigon 25th Anniversary Performance (2016) | £19,825 | £27,576 | £2,057,031 | 86% | 5 |
| 21 (25) |  | The Beatles: Eight Days a Week - The Touring Years () | £19,312 | £31,128 | £1,139,704 | 72% | 9 |
| 22 (new) | | Lahore Se Aagey (2016) | £16,651 | £16,651 | £16,651 | new | 1 |
| 23 (new) | | Kobiety Bez Wstydu () | £12,879 | £12,879 | £12,879 | new | 1 |
| 24 (new) | | Francofonia (2016) | £8,785 | £8,785 | £8,785 | new | 1 |
| 25 (29) |  | Ethel and Ernest (2016) | £7,650 | £16,242 | £56,301 | 60% | 3 |
| 26 (22) |  | American Honey () | £7,321 | £12,375 | £454,304 | -4% | 5 |
| 27 (21) | | My Scientology Movie (2016) | £6,601 | £22,109 | £1,070,886 | -34% | 6 |
| 28 (33) |  | Anthropoid (2016) | £6,297 | £14,433 | £815,140 | 75% | 10 |
| 29 (new) | | Moscow Never Sleeps () | £5,549 | £5,549 | £5,549 | new | 1 |
| 30 (new) | | Achcham Yenbadhu Madamaiyada () | £3,838 | £3,838 | £3,838 | new | 1 |
| 31 (40) |  | Swallows and Amazons () | £3,623 | £9,543 | £3,075,044 | 81% | 13 |
| 32 (24) |  | Supersonic () | £2,129 | £5,501 | £746,166 | -65% | 6 |
| 33 (45) | | War On Everyone (2016) | £2,037 | £2,116 | £415,623 | 91% | 6 |
| 34 (re) | | Saul: Glyndebourne 2016 (2016) | £2,013 | £2,013 | £18,511 | re | 1 |
| 35 (new) | | Hacienda Classical the Classical Rave (2016) | £1,068 | £1,068 | £1,068 | new | 1 |
| 36 (re) |  | The Childhood of a Leader (2016) | £729 | £729 | £169,762 | re | 8 |
| 37 (34) | | King Lear: RSC Live 2016 () | £639 | £5,209 | £425,302 | -54% | 5 |
| 38 (38) | | The Darkest Universe () | £611 | £1,378 | £2,282 | -32% | 2 |
| 39 (32) |  | Starfish (2016) | £427 | £9,108 | £30,121 | -80% | 3 |
| 40 (41) | | Burn Burn Burn (2016) | £336 | £1,278 | £13,507 | -49% | 3 |
| 41 (re) | | In Pursuit of Silence (2016) | £255 | £255 | £9,587 | re | 2 |
| 42 (new) | | 100 Streets (2016) | £245 | £245 | £245 | new | 1 |
| 43 (43) |  | Brotherhood () | £176 | £338 | £3,696,458 | -43% | 11 |
| 44 (47) |  | The Girl With All the Gifts () | £136 | £452 | £1,073,340 | -12% | 8 |
| 45 (36) |  | The Infiltrator (2016) | £129 | £767 | £1,083,631 | -89% | 9 |