| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Conjuring 2: The Enfield Case () | £4,637,862 | £4,637,862 | £4,637,862 | new | 1 |
| 2 (1) |  | Me Before You () | £979,126 | £2,059,142 | £6,537,142 | -33% | 3 |
| 3 (new) |  | Gods of Egypt (2016) | £484,467 | £484,467 | £484,467 | new | 1 |
| 4 (2) |  | Teenage Mutant Ninja Turtles: Out of the Shadows () | £438,885 | £676,560 | £5,478,327 | -48% | 3 |
| 5 (3) |  | Alice Through the Looking Glass (2016) | £418,384 | £685,671 | £8,992,310 | -50% | 4 |
| 6 (6) |  | The Nice Guys () | £414,147 | £794,724 | £3,027,358 | -35% | 3 |
| 7 (5) |  | X-Men: Apocalypse (2016) | £380,092 | £693,004 | £17,760,690 | -46% | 5 |
| 8 (4) |  | Warcraft () | £320,910 | £664,975 | £5,687,259 | -56% | 3 |
| 9 (7) |  | The Boss (2016) | £297,764 | £683,153 | £1,277,825 | -50% | 2 |
| 10 (8) |  | The Angry Birds Movie () | £238,692 | £308,838 | £9,738,953 | -59% | 6 |
| 11 (10) |  | The Jungle Book () | £234,074 | £318,145 | £45,429,826 | -43% | 10 |
| 12 (9) |  | Mother's Day () | £152,188 | £451,173 | £870,705 | -64% | 2 |
| 13 (new) |  | Tale of Tales (2015) | £119,310 | £119,310 | £119,310 | new | 1 |
| 14 (12) |  | Love and Friendship () | £107,089 | £249,753 | £1,422,146 | -37% | 4 |
| 15 (new) |  | Barbershop: A Fresh Cut (2016) | £91,502 | £91,502 | £91,502 | new | 1 |
| 16 (new) | | Udta Punjab () | £86,367 | £86,367 | £86,367 | new | 1 |
| 17 (new) |  | The Keeping Room (2015) | £26,199 | £26,199 | £26,199 | new | 1 |
| 18 (23) |  | Our Kind of Traitor (2016) | £17,222 | £35,421 | £1,168,169 | 11% | 6 |
| 19 (21) |  | Florence Foster Jenkins () | £11,410 | £40,537 | £3,088,142 | -37% | 7 |
| 20 (new) | | Where You're Meant to Be () | £11,349 | £11,349 | £11,349 | new | 1 |
| 21 (new) | | Bang Gang (2016) | £9,305 | £9,305 | £9,305 | new | 1 |
| 22 (27) |  | Thomas & Friends: The Great Race (2016) | £6,187 | £6,911 | £290,468 | 26% | 5 |
| 23 (25) |  | Eye In the Sky () | £5,493 | £21,304 | £5,016,225 | -43% | 10 |
| 24 (new) | | Enakku Innoru Per Irukku (2016) | £5,285 | £5,285 | £5,285 | new | 1 |
| 25 (new) | | #wszystkogra (2016) | £4,721 | £4,721 | £4,721 | new | 1 |
| 26 (29) |  | A Hologram For the King (2016) | £4,497 | £9,267 | £771,589 | 10% | 5 |
| 27 (new) |  | Cemetery of Splendour () | £3,674 | £3,674 | £3,674 | new | 1 |
| 28 (31) | | Globe On Screen: The Merchant of Venice Shakespeares Globe 2015 () | £3,368 | £21,499 | £24,463 | 12% | 2 |
| 29 (new) | | Kammatipaadam () | £2,628 | £2,628 | £2,628 | new | 1 |
| 30 (22) |  | The Audience: NT Live 2013 () | £2,557 | £31,536 | £2,230,559 | -84% | 2 |
| 31 (36) |  | Eddie the Eagle () | £1,449 | £20,129 | £8,646,649 | 22% | 12 |
| 32 (new) | | The Violators () | £1,248 | £1,248 | £1,248 | new | 1 |
| 33 (new) |  | Long Way North () | £1,182 | £1,182 | £1,182 | new | 1 |
| 34 (37) | | Matthew Bourne's the Car Man 2015 (2016) | £878 | £878 | £84,465 | 13% | 8 |
| 35 (35) |  | Golden Years () | £624 | £6,711 | £69,226 | -54% | 7 |
| 36 (34) |  | Versus: The Life and Films of Ken Loach (2016) | £562 | £6,564 | £32,524 | -64% | 3 |
| 37 (new) | | Down By Love () | £550 | £550 | £550 | new | 1 |
| 38 (new) |  | The Girl King () | £513 | £513 | £513 | new | 1 |
| 39 (re) | | Breaking the Bank () | £388 | £388 | £3,341 | re | 2 |
| 40 (39) | | Hamlet: RSC Live 2016 () | £311 | £10,257 | £264,313 | -51% | 2 |
| 41 (28) |  | The Man Who Knew Infinity (2016) | £241 | £3,985 | £534,398 | -94% | 11 |
| 42 (38) |  | Departure (2016) | £170 | £2,133 | £19,293 | -75% | 5 |
| 43 (43) |  | High Rise (2016) | £105 | £1,730 | £1,967,710 | 26% | 14 |