| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Conjuring 2: The Enfield Case (2016) | £4,637,862 | £4,637,862 | £4,637,862 | new | 1 |
| 2 (1) |  | Me Before You (2016) | £979,126 | £2,059,142 | £6,537,142 | -33% | 3 |
| 3 (new) |  | Gods of Egypt (2016) | £484,467 | £484,467 | £484,467 | new | 1 |
| 4 (2) |  | Teenage Mutant Ninja Turtles: Out of the Shadows (2016) | £438,885 | £676,560 | £5,478,327 | -48% | 3 |
| 5 (3) |  | Alice Through the Looking Glass (2016) | £418,384 | £685,671 | £8,992,310 | -50% | 4 |
| 6 (6) |  | The Nice Guys (2016) | £414,147 | £794,724 | £3,027,358 | -35% | 3 |
| 7 (5) |  | X-Men: Apocalypse (2016) | £380,092 | £693,004 | £17,760,690 | -46% | 5 |
| 8 (4) |  | Warcraft (2016) | £320,910 | £664,975 | £5,687,259 | -56% | 3 |
| 9 (7) |  | The Boss (2016) | £297,764 | £683,153 | £1,277,825 | -50% | 2 |
| 10 (8) |  | The Angry Birds Movie (2016) | £238,692 | £308,838 | £9,738,953 | -59% | 6 |
| 11 (10) |  | The Jungle Book (2016) | £234,074 | £318,145 | £45,429,826 | -43% | 10 |
| 12 (9) |  | Mother's Day (2016) | £152,188 | £451,173 | £870,705 | -64% | 2 |
| 13 (new) |  | Tale of Tales (2015) | £119,310 | £119,310 | £119,310 | new | 1 |
| 14 (12) |  | Love and Friendship (2016) | £107,089 | £249,753 | £1,422,146 | -37% | 4 |
| 15 (new) |  | Barbershop: A Fresh Cut (2016) | £91,502 | £91,502 | £91,502 | new | 1 |