| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Harry Potter and the Deathly Hallows Part 1 (2010) | £8,344,776 | £14,938,159 | £33,257,880 | -54% | 2 |
| 2 (new) |  | Unstoppable (2010) | £1,714,871 | £1,714,871 | £1,714,871 | new | 1 |
| 3 (new) |  | London Boulevard (2010) | £577,224 | £577,224 | £577,224 | new | 1 |
| 4 (2) |  | Due Date (2010) | £560,179 | £1,184,796 | £9,208,287 | -54% | 4 |
| 5 (new) |  | The American (2010) | £411,707 | £411,707 | £411,707 | new | 1 |
| 6 (3) |  | Despicable Me (2010) | £241,944 | £327,803 | £19,394,633 | -63% | 7 |
| 7 (new) |  | The Girl Who Kicked the Hornets Nest (2010) | £219,259 | £219,259 | £219,259 | new | 1 |
| 8 (5) |  | Jackass 3D (2010) | £119,369 | £369,492 | £5,437,656 | -66% | 4 |
| 9 (4) |  | Skyline (2010) | £92,931 | £313,097 | £2,645,267 | -82% | 3 |
| 10 (new) |  | Machete (2010) | £90,423 | £90,423 | £90,423 | new | 1 |
| 11 (new) | | Break Ke Baad (2010) | £85,708 | £85,708 | £85,708 | new | 1 |
| 12 (10) |  | Another Year (2010) | £59,505 | £168,760 | £1,443,577 | -63% | 4 |
| 13 (7) |  | Alpha and Omega (2010) | £58,293 | £66,580 | £2,939,702 | -70% | 6 |
| 14 (9) |  | The Social Network (2010) | £50,943 | £127,732 | £10,306,540 | -70% | 7 |
| 15 (8) |  | Guzaarish (2010) | £48,952 | £132,969 | £303,996 | -71% | 2 |
| 16 (17) |  | Made In Dagenham (2010) | £8,860 | £17,915 | £3,631,485 | -20% | 9 |
| 17 (re) |  | Burke and Hare (2010) | £6,521 | £6,521 | £2,329,151 | re | 4 |
| 18 (new) | | Nandalala (2010) | £3,137 | £3,137 | £3,137 | new | 1 |
| 19 (new) | | Leap Year (2010) | £2,424 | £2,424 | £2,424 | new | 1 |
| 20 (new) |  | An Ordinary Execution (2010) | £2,326 | £2,326 | £2,326 | new | 1 |
| 21 (new) | | Sleeping Princess (2010) | £1,692 | £1,692 | £1,692 | new | 1 |
| 22 (18) | | Africa United (2010) | £1,491 | £5,426 | £668,458 | -80% | 6 |
| 23 (re) | | The Illusionist (2010) | £1,296 | £1,296 | £904,848 | re | 14 |
| 24 (new) | | Waiting For "Superman" (2010) | £1,022 | £1,022 | £1,022 | new | 1 |
| 25 (new) | | Allah Ke Banday (2010) | £682 | £682 | £682 | new | 1 |
| 26 (22) |  | Mr. Nice (2010) | £254 | £2,666 | £763,221 | -85% | 8 |
| 27 (26) | | Over Your Cities Grass Will Grow (2010) | £58 | £134 | £11,885 | -42% | 7 |
| 28 (21) | | The Arbor (2010) | £24 | £1,824 | £58,875 | -99% | 6 |