| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Harry Potter and the Deathly Hallows Part 1 () | £18,319,721 | £18,319,721 | £18,319,721 | new | 1 |
| 2 (1) |  | Due Date (2010) | £1,218,115 | £2,270,612 | £8,023,491 | -36% | 3 |
| 3 (3) |  | Despicable Me (2010) | £648,479 | £894,980 | £19,066,830 | -40% | 6 |
| 4 (2) |  | Skyline (2010) | £513,338 | £1,125,963 | £2,332,170 | -57% | 2 |
| 5 (4) |  | Jackass 3D () | £349,096 | £1,066,764 | £5,068,164 | -67% | 3 |
| 6 (6) |  | Red () | £222,059 | £472,447 | £6,840,646 | -56% | 5 |
| 7 (9) |  | Alpha and Omega (2010) | £192,823 | £233,281 | £2,873,122 | -35% | 5 |
| 8 (new) |  | Guzaarish (2010) | £171,027 | £171,027 | £171,027 | new | 1 |
| 9 (7) |  | The Social Network (2010) | £170,846 | £397,412 | £10,178,808 | -60% | 6 |
| 10 (10) |  | Another Year (2010) | £161,966 | £360,762 | £1,274,817 | -46% | 3 |
| 11 (8) |  | Paranormal Activity 2 (2010) | £124,087 | £331,073 | £10,937,805 | -68% | 5 |
| 12 (5) |  | Saw: The Final Chapter () | £105,467 | £450,405 | £8,022,330 | -80% | 4 |
| 13 (new) | | Chico and Rita (2010) | £81,172 | £81,172 | £81,172 | new | 1 |
| 14 (14) |  | The Kids Are All Right () | £77,337 | £174,534 | £1,485,900 | -52% | 4 |
| 15 (11) |  | Let Me In () | £69,505 | £257,696 | £1,352,772 | -76% | 3 |
| 16 (new) |  | Uncle Boonmee: Who Can Recall His Past Lives () | £27,452 | £27,452 | £27,452 | new | 1 |
| 17 (17) |  | Made In Dagenham (2010) | £11,124 | £56,623 | £3,613,570 | -67% | 8 |
| 18 (19) | | Africa United () | £7,400 | £20,606 | £663,032 | -64% | 5 |
| 19 (new) | | Dream Home () | £2,820 | £2,820 | £2,820 | new | 1 |
| 20 (new) | | Fathers of Girls () | £1,807 | £1,807 | £1,807 | new | 1 |
| 21 (22) | | The Arbor (2010) | £1,771 | £3,878 | £57,051 | 13% | 5 |
| 22 (21) |  | Mr. Nice () | £1,668 | £4,501 | £760,555 | -39% | 7 |
| 23 (24) |  | Soulboy (2010) | £1,112 | £1,271 | £88,227 | 52% | 10 |
| 24 (new) | | Adrift () | £930 | £930 | £930 | new | 1 |
| 25 (25) |  | Tamara Drewe (2010) | £143 | £5,363 | £2,570,502 | -36% | 11 |
| 26 (23) | | Over Your Cities Grass Will Grow () | £100 | £862 | £11,751 | -91% | 6 |
| 27 (27) |  | Brilliantlove (2010) | £20 | £1,015 | £1,078 | -68% | 2 |