| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Due Date (2010) | £2,346,089 | £2,346,089 | £2,346,089 | new | 1 |
| 2 (new) |  | Jackass 3D (2010) | £1,696,909 | £1,696,909 | £1,696,909 | new | 1 |
| 3 (2) |  | Despicable Me (2010) | £1,177,507 | £1,794,041 | £16,863,318 | -54% | 4 |
| 4 (1) |  | Saw: The Final Chapter (2010) | £1,068,403 | £2,807,997 | £6,408,080 | -70% | 2 |
| 5 (3) |  | Paranormal Activity 2 (2010) | £687,747 | £1,577,652 | £9,876,254 | -63% | 3 |
| 6 (4) |  | Red (2010) | £595,362 | £1,212,919 | £5,553,877 | -50% | 3 |
| 7 (5) |  | The Social Network (2010) | £541,763 | £1,161,763 | £9,029,931 | -49% | 4 |
| 8 (new) |  | Let Me In (2010) | £488,172 | £488,172 | £488,172 | new | 1 |
| 9 (new) |  | Another Year (2010) | £355,626 | £355,626 | £355,626 | new | 1 |
| 10 (6) |  | Burke and Hare (2010) | £333,637 | £797,821 | £1,740,715 | -65% | 2 |
| 11 (new) | | Golmaal 3 (2010) | £259,611 | £259,611 | £259,611 | new | 1 |
| 12 (9) |  | The Kids Are All Right (2010) | £249,110 | £569,297 | £981,257 | -40% | 2 |
| 13 (8) |  | Alpha and Omega (2010) | £230,543 | £310,962 | £2,318,181 | -50% | 3 |
| 14 (7) |  | Legend of the Guardians: The Owls of Ga'hoole (2010) | £217,775 | £630,166 | £2,813,519 | -57% | 3 |
| 15 (new) |  | Action Replayy (2010) | £154,911 | £154,911 | £154,911 | new | 1 |
| 16 (15) |  | Made In Dagenham (2010) | £36,146 | £142,516 | £3,450,229 | -62% | 6 |
| 17 (14) | | Africa United (2010) | £30,519 | £64,355 | £609,911 | -71% | 3 |
| 18 (20) | | The Illusionist (2010) | £4,803 | £12,322 | £883,010 | 22% | 12 |
| 19 (16) |  | Mr. Nice (2010) | £4,439 | £30,241 | £747,322 | -83% | 5 |
| 20 (23) |  | Tamara Drewe (2010) | £2,149 | £10,284 | £2,562,847 | 86% | 9 |
| 21 (18) | | The Arbor (2010) | £1,921 | £9,729 | £49,220 | -74% | 3 |
| 22 (17) |  | Jhootha Hi Sahi (2010) | £702 | £7,237 | £78,289 | -96% | 3 |
| 23 (24) |  | Soulboy (2010) | £532 | £532 | £83,787 | 45% | 8 |
| 24 (25) | | Over Your Cities Grass Will Grow (2010) | £125 | £327 | £9,731 | 14% | 4 |
| 25 (new) |  | Red and White (2010) | £87 | £87 | £87 | new | 1 |