| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Saw: The Final Chapter (2010) | £3,600,083 | £3,600,083 | £3,600,083 | new | 1 |
| 2 (2) |  | Despicable Me (2010) | £2,581,073 | £7,483,929 | £15,069,277 | 0% | 3 |
| 3 (1) |  | Paranormal Activity 2 (2010) | £1,845,337 | £4,533,880 | £8,298,602 | -51% | 2 |
| 4 (3) |  | Red (2010) | £1,184,344 | £2,678,486 | £4,340,958 | -29% | 2 |
| 5 (4) |  | The Social Network (2010) | £1,070,411 | £2,509,059 | £7,868,168 | -30% | 3 |
| 6 (new) |  | Burke and Hare (2010) | £942,894 | £942,894 | £942,894 | new | 1 |
| 7 (5) |  | Legend of the Guardians: The Owls of Ga'hoole (2010) | £502,951 | £1,445,909 | £2,183,353 | -32% | 2 |
| 8 (6) |  | Alpha and Omega (2010) | £458,812 | £1,363,794 | £2,007,219 | -29% | 2 |
| 9 (new) |  | The Kids Are All Right (2010) | £411,960 | £411,960 | £411,960 | new | 1 |
| 10 (7) |  | Vampires Suck (2010) | £313,911 | £965,883 | £2,990,692 | -41% | 3 |
| 11 (8) |  | Easy A (2010) | £149,044 | £495,820 | £773,795 | -46% | 2 |
| 12 (10) |  | Wall Street: Money Never Sleeps (2010) | £124,832 | £286,223 | £3,984,300 | -52% | 4 |
| 13 (9) |  | Life As We Know It (2010) | £124,360 | £372,641 | £3,291,887 | -53% | 4 |
| 14 (11) | | Africa United (2010) | £105,151 | £367,729 | £545,556 | -41% | 2 |
| 15 (12) |  | Made In Dagenham (2010) | £94,110 | £286,094 | £3,307,713 | -40% | 5 |
| 16 (16) |  | Mr. Nice (2010) | £26,331 | £58,824 | £717,081 | -31% | 4 |
| 17 (17) |  | Jhootha Hi Sahi (2010) | £15,823 | £38,367 | £71,052 | -52% | 2 |
| 18 (18) | | The Arbor (2010) | £7,532 | £22,608 | £39,491 | -55% | 2 |
| 19 (new) | | The Hunter (2010) | £5,777 | £5,777 | £5,777 | new | 1 |
| 20 (21) | | The Illusionist (2010) | £3,755 | £15,037 | £870,688 | -34% | 11 |
| 21 (new) | | Involuntary (2010) | £2,426 | £2,426 | £2,426 | new | 1 |
| 22 (new) |  | Spiderhole (2010) | £1,422 | £1,422 | £1,422 | new | 1 |
| 23 (22) |  | Tamara Drewe (2010) | £294 | £15,346 | £2,552,563 | -94% | 8 |
| 24 (23) |  | Soulboy (2010) | £292 | £1,959 | £83,255 | -83% | 7 |
| 25 (24) | | Over Your Cities Grass Will Grow (2010) | £108 | £1,769 | £9,404 | -83% | 3 |