| Title | Weekend | Week | Total | % Change | Total Weeks | ||
| 1 (1) | ![]() | Toy Story 3 (2010) | £8,115,193 | £18,603,959 | £39,791,223 | -62% | 2 |
| 2 (new) | ![]() | The Karate Kid (2010) | £4,882,306 | £4,882,306 | £4,882,306 | new | 1 |
| 3 (new) | ![]() | The A-Team () | £3,569,505 | £3,569,505 | £3,569,505 | new | 1 |
| 4 (2) | ![]() | Inception (2010) | £3,229,651 | £6,595,947 | £20,800,468 | -23% | 3 |
| 5 (4) | ![]() | Shrek Forever After (2010) | £899,851 | £2,314,819 | £29,193,540 | -26% | 5 |
| 6 (3) | ![]() | The Twilight Saga: Eclipse (2010) | £779,142 | £2,144,954 | £27,781,259 | -46% | 4 |
| 7 (5) | ![]() | The Rebound () | £178,972 | £556,556 | £916,571 | -50% | 2 |
| 8 (new) | Gainsbourg (2010) | £135,031 | £135,031 | £135,031 | new | 1 | |
| 9 (6) | ![]() | Predators () | £112,088 | £337,397 | £5,639,739 | -63% | 4 |
| 10 (new) | Once Upon a Time In Mumbaai () | £54,780 | £54,780 | £54,780 | new | 1 | |
| 11 (7) | Khatta Meetha (2010) | £46,851 | £125,101 | £249,205 | -62% | 2 | |
| 12 (8) | ![]() | Get Him to the Greek () | £44,001 | £137,098 | £6,946,757 | -63% | 6 |
| 13 (9) | Splice () | £34,478 | £129,313 | £239,538 | -69% | 2 | |
| 14 (re) | ![]() | Tooth Fairy (2010) | £27,576 | £27,576 | £3,795,741 | re | 9 |
| 15 (11) | Heartbreaker (2010) | £21,519 | £56,435 | £596,009 | -39% | 5 | |
| 16 (new) | South of the Border (2010) | £20,591 | £20,591 | £20,591 | new | 1 | |
| 17 (17) | ![]() | Nanny Mcphee and the Big Bang (2010) | £10,227 | £10,912 | £16,440,012 | -11% | 19 |
| 18 (new) | ![]() | Beautiful Kate () | £6,538 | £6,538 | £6,538 | new | 1 |
| 19 (22) | ![]() | StreetDance 3D (2010) | £3,568 | £10,614 | £11,615,398 | -17% | 11 |
| 20 (23) | ![]() | Robin Hood () | £3,177 | £6,835 | £15,435,578 | 13% | 12 |
| 21 (21) | ![]() | Four Lions () | £2,822 | £6,080 | £2,928,884 | -42% | 13 |
| 22 (20) | London River () | £2,501 | £9,833 | £62,320 | -51% | 4 | |
| 23 (26) | ![]() | The Ghost () | £2,204 | £4,099 | £4,071,548 | 60% | 16 |
| 24 (new) | ![]() | Down Terrace () | £1,919 | £1,919 | £1,919 | new | 1 |
| 25 (25) | Went the Day Well? (1942) Rerelease | £1,150 | £1,944 | £15,149 | -10% | 3 | |
| 26 (27) | ![]() | Wild Target (2010) | £855 | £2,769 | £786,324 | 21% | 6 |
| 27 (new) | Separado () | £540 | £540 | £540 | new | 1 | |
| 28 (28) | ![]() | 4.3.2.1 (2010) | £23 | £177 | £984,040 | -78% | 9 |