| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Shrek Forever After (2010) | £8,955,554 | £8,955,554 | £8,955,554 | new | 1 |
| 2 (1) |  | Get Him to the Greek () | £1,048,898 | £2,292,057 | £3,861,613 | -33% | 2 |
| 3 (2) |  | Killers () | £274,768 | £642,693 | £2,506,529 | -29% | 3 |
| 4 (3) |  | Sex and the City 2 () | £212,501 | £635,592 | £20,988,763 | -40% | 6 |
| 5 (new) |  | I Hate Luv Storys (2010) | £202,907 | £202,907 | £202,907 | new | 1 |
| 6 (new) | | Heartbreaker (2010) | £119,742 | £119,742 | £119,742 | new | 1 |
| 7 (4) |  | Prince of Persia: The Sands of Time (2010) | £92,682 | £256,738 | £8,613,702 | -42% | 7 |
| 8 (6) |  | Death At a Funeral () | £68,609 | £213,239 | £2,628,181 | -42% | 5 |
| 9 (7) | | The Collector (2010) | £65,042 | £203,301 | £312,820 | -41% | 2 |
| 10 (13) | | Whatever Works (2010) | £49,321 | £130,877 | £203,555 | -32% | 2 |
| 11 (9) |  | Robin Hood () | £45,899 | £191,115 | £15,295,536 | -49% | 8 |
| 12 (11) |  | Tooth Fairy (2010) | £45,135 | £97,434 | £3,597,267 | -42% | 6 |
| 13 (5) |  | StreetDance 3D (2010) | £43,797 | £208,138 | £11,488,200 | -72% | 7 |
| 14 (8) |  | Letters to Juliet (2010) | £42,451 | £198,387 | £1,968,536 | -59% | 4 |
| 15 (12) |  | Brooklyn's Finest () | £38,973 | £127,554 | £1,252,604 | -49% | 4 |
| 16 (new) | | White Material () | £31,763 | £31,763 | £31,763 | new | 1 |
| 17 (16) |  | Four Lions () | £16,973 | £37,647 | £2,846,506 | -5% | 9 |
| 18 (new) |  | When You're Strange (2010) | £12,461 | £12,461 | £12,461 | new | 1 |
| 19 (22) |  | Nanny Mcphee and the Big Bang (2010) | £11,135 | £11,819 | £16,393,224 | 80% | 15 |
| 20 (18) |  | The Killer Inside Me (2010) | £7,088 | £25,673 | £437,244 | -32% | 5 |
| 21 (19) |  | 4.3.2.1 (2010) | £3,739 | £19,130 | £973,972 | -63% | 5 |
| 22 (new) |  | Lymelife () | £2,754 | £2,754 | £2,754 | new | 1 |
| 23 (21) |  | Black Death () | £1,732 | £6,236 | £126,254 | -43% | 4 |
| 24 (25) |  | The Ghost () | £690 | £1,351 | £4,052,299 | 64% | 12 |
| 25 (new) |  | Crimefighters () | £441 | £441 | £441 | new | 1 |
| 26 (new) | | Chega De Saudade (2010) | £141 | £141 | £141 | new | 1 |
| 27 (new) |  | Skeletons () | £43 | £43 | £43 | new | 1 |
| 28 (24) |  | American: The Bill Hicks Story () | £20 | £2,494 | £118,783 | -97% | 8 |
| 29 (26) | | The Infidel () | £20 | £141 | £590,219 | -79% | 13 |