| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Iron Man 2 () | £7,664,732 | £7,664,732 | £7,664,732 | new | 1 |
| 2 (3) |  | How to Train Your Dragon (2010) | £843,663 | £1,015,862 | £15,272,853 | 3% | 5 |
| 3 (1) |  | Date Night () | £783,393 | £1,352,756 | £2,625,161 | -38% | 2 |
| 4 (new) |  | The Last Song () | £679,698 | £679,698 | £679,698 | new | 1 |
| 5 (2) |  | Clash of the Titans () | £659,005 | £1,131,077 | £19,201,856 | -33% | 5 |
| 6 (4) |  | Dear John (2010) | £608,637 | £1,050,975 | £4,627,618 | -25% | 3 |
| 7 (6) |  | The Ghost () | £548,270 | £913,899 | £2,961,437 | -13% | 3 |
| 8 (5) |  | Kick-Ass () | £402,864 | £750,114 | £10,991,324 | -37% | 5 |
| 9 (8) |  | Nanny Mcphee and the Big Bang (2010) | £388,832 | £462,217 | £15,631,528 | -2% | 6 |
| 10 (new) |  | House Full () | £262,752 | £262,752 | £262,752 | new | 1 |
| 11 (7) |  | It's a Wonderful Afterlife (2010) | £175,224 | £349,414 | £813,882 | -62% | 2 |
| 12 (new) |  | The Disappearance of Alice Creed () | £142,324 | £142,324 | £142,324 | new | 1 |
| 13 (9) |  | Alice In Wonderland () | £139,995 | £253,716 | £42,169,542 | -50% | 9 |
| 14 (10) |  | The Joneses () | £110,809 | £267,502 | £514,680 | -55% | 2 |
| 15 (11) |  | Cemetery Junction (2010) | £75,570 | £196,054 | £1,329,002 | -63% | 2 |
| 16 (13) |  | Centurion () | £43,010 | £126,798 | £240,945 | -62% | 2 |
| 17 (16) | | The Infidel () | £42,562 | £74,632 | £517,582 | -36% | 4 |
| 18 (new) | | Revanche () | £9,946 | £9,946 | £9,946 | new | 1 |
| 19 (24) | | Perriers Bounty () | £3,512 | £7,377 | £339,190 | -41% | 6 |
| 20 (new) | | Valhalla Rising () | £3,287 | £3,287 | £3,287 | new | 1 |
| 21 (31) |  | An Education () | £2,588 | £53,607 | £2,583,408 | 80% | 25 |
| 22 (26) |  | No Greater Love () | £2,243 | £4,917 | £16,136 | -37% | 4 |
| 23 (new) |  | The Milk of Sorrow (2010) | £1,843 | £1,843 | £1,843 | new | 1 |
| 24 (23) |  | Cherrybomb () | £1,745 | £7,304 | £14,164 | -75% | 2 |
| 25 (25) |  | Planet 51 () | £1,742 | £1,987 | £5,037,866 | -70% | 21 |
| 26 (new) | | A Boy Called Dad () | £1,736 | £1,736 | £1,736 | new | 1 |
| 27 (new) |  | Gentlemen Broncos (2009) | £1,125 | £1,125 | £1,125 | new | 1 |
| 28 (32) | | Crying With Laughter () | £831 | £903 | £7,707 | 94% | 3 |
| 29 (29) |  | Exit Through the Gift Shop (2010) | £755 | £2,012 | £308,181 | 18% | 9 |
| 30 (new) | | Erasing David (2010) | £298 | £298 | £298 | new | 1 |