| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Avatar () | £5,155,844 | £8,066,607 | £57,441,123 | -7% | 6 |
| 2 (2) |  | Sherlock Holmes () | £1,632,172 | £2,543,366 | £21,372,499 | -20% | 5 |
| 3 (3) |  | Alvin and the Chipmunks: The Squeakquel (2009) | £1,454,278 | £1,700,521 | £18,563,223 | -6% | 5 |
| 4 (5) |  | Up In the Air (2009) | £1,205,881 | £1,984,489 | £3,282,512 | -7% | 2 |
| 5 (4) |  | Its Complicated () | £1,140,684 | £2,106,396 | £5,397,653 | -12% | 3 |
| 6 (re) |  | Toy Story 2 (1999) | £909,093 | £909,093 | £44,400,114 | re | 13 |
| 7 (6) |  | The Book of Eli (2010) | £825,508 | £1,404,077 | £2,636,078 | -33% | 2 |
| 8 (7) |  | Daybreakers (2009) | £420,199 | £784,583 | £3,521,958 | -48% | 3 |
| 9 (new) |  | Brother's (2010) | £366,290 | £366,290 | £366,290 | new | 1 |
| 10 (new) | | A Prophet () | £312,237 | £312,237 | £312,237 | new | 1 |
| 11 (8) |  | The Road (2010) | £255,486 | £494,375 | £2,004,350 | -46% | 3 |
| 12 (9) |  | Did You Hear About the Morgans? () | £198,931 | £373,464 | £3,339,675 | -50% | 4 |
| 13 (10) |  | St. Trinian's 2: The Legend of Frittons Gold (2009) | £197,615 | £242,968 | £6,788,842 | -30% | 6 |
| 14 (new) |  | Ninja Assassin () | £187,285 | £187,285 | £187,285 | new | 1 |
| 15 (new) |  | Veer () | £148,423 | £148,423 | £148,423 | new | 1 |
| 16 (16) |  | Planet 51 () | £79,292 | £81,655 | £4,611,335 | -12% | 8 |
| 17 (13) |  | Nine (2009) | £77,525 | £189,497 | £3,000,607 | -48% | 6 |
| 18 (new) | | Armoured (2010) | £64,931 | £64,931 | £64,931 | new | 1 |
| 19 (12) |  | 44 Inch Chest (2010) | £64,525 | £152,416 | £304,587 | -58% | 2 |
| 20 (new) |  | The Boys Are Back () | £64,465 | £64,465 | £64,465 | new | 1 |
| 21 (14) |  | Sex & Drugs & Rock & Roll () | £61,384 | £137,645 | £565,601 | -54% | 3 |
| 22 (18) |  | Nowhere Boy () | £32,391 | £70,263 | £1,148,712 | -27% | 5 |
| 23 (22) |  | An Education () | £21,124 | £37,517 | £2,035,359 | 70% | 12 |
| 24 (20) |  | Fantastic Mr. Fox () | £18,758 | £21,688 | £8,968,314 | -21% | 13 |
| 25 (23) | | Mugabe and the White African () | £6,073 | £12,947 | £28,942 | 12% | 3 |
| 26 (26) |  | Glorious 39 (2009) | £3,847 | £7,032 | £270,409 | 14% | 9 |
| 27 (25) | | Bright Star () | £1,495 | £5,658 | £1,044,554 | -61% | 11 |
| 28 (28) |  | Nativity! () | £1,315 | £1,810 | £5,178,373 | -51% | 9 |
| 29 (new) | | Burlesque Undressed (2010) | £1,274 | £1,274 | £1,274 | new | 1 |
| 30 (27) |  | Harry Brown (2009) | £1,239 | £3,759 | £4,552,486 | -59% | 10 |
| 31 (30) | | Me and Orson Welles (2008) | £1,194 | £1,950 | £440,537 | -46% | 7 |
| 32 (29) |  | The Imaginarium of Doctor Parnassus () | £460 | £1,772 | £3,928,404 | -82% | 14 |
| 33 (32) | | Cracks () | £407 | £2,081 | £102,848 | -67% | 7 |
| 34 (34) |  | Bunny and the Bull (2009) | £228 | £1,559 | £85,775 | 35% | 8 |