| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | You, Me and Dupree () | £1,165,610 | £2,815,742 | £4,451,991 | -29% | 2 |
| 2 (new) |  | Little Man () | £1,090,761 | £1,090,761 | £1,090,761 | new | 1 |
| 3 (new) |  | The Wicker Man () | £736,316 | £736,316 | £736,316 | new | 1 |
| 4 (new) |  | The Sentinel () | £627,838 | £627,838 | £627,838 | new | 1 |
| 5 (4) |  | Cars () | £489,013 | £1,202,380 | £15,444,700 | -12% | 6 |
| 6 (3) |  | Pirates of the Caribbean: Dead Man's Chest () | £485,631 | £1,191,534 | £51,044,338 | -23% | 9 |
| 7 (5) |  | Monster House () | £467,331 | £1,157,867 | £5,655,181 | -11% | 4 |
| 8 (new) |  | Crank (2006) | £450,141 | £450,141 | £450,141 | new | 1 |
| 9 (8) |  | Volver () | £395,462 | £822,437 | £1,255,720 | -9% | 2 |
| 10 (2) |  | Snakes On a Plane (2006) | £368,907 | £1,030,204 | £3,692,064 | -47% | 3 |
| 11 (new) | | Open Water 2 Adrift (2006) | £337,718 | £337,718 | £337,718 | new | 1 |
| 12 (6) |  | John Tucker Must Die (2006) | £308,351 | £901,013 | £3,197,999 | -39% | 3 |
| 13 (7) |  | Severance (2006) | £283,323 | £823,399 | £1,306,551 | -41% | 2 |
| 14 (11) |  | Garfield 2 () | £248,740 | £622,045 | £5,969,059 | 2% | 7 |
| 15 (new) |  | Lage Raho Munna Bhai (2006) | £233,158 | £233,158 | £233,158 | new | 1 |
| 16 (17) |  | Thank You For Smoking () | £5,883 | £29,696 | £1,534,405 | -25% | 11 |
| 17 (20) |  | Tideland () | £4,592 | £16,203 | £54,640 | 69% | 3 |
| 18 (19) |  | Little Fish () | £4,253 | £9,950 | £305,187 | 61% | 7 |
| 19 (18) |  | Renaissance (2006) | £1,416 | £4,930 | £77,719 | -32% | 5 |