| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Snakes On a Plane (2006) | £1,069,608 | £1,069,608 | £1,069,608 | new | 1 |
| 2 (1) |  | Cars () | £943,377 | £2,191,619 | £12,820,576 | -30% | 4 |
| 3 (2) |  | Pirates of the Caribbean: Dead Man's Chest () | £906,837 | £2,018,652 | £48,405,649 | -31% | 7 |
| 4 (4) |  | Monster House () | £855,621 | £2,072,162 | £3,102,467 | -17% | 2 |
| 5 (new) |  | John Tucker Must Die (2006) | £845,633 | £845,633 | £845,633 | new | 1 |
| 6 (5) |  | Nacho Libre () | £611,692 | £1,465,355 | £2,459,303 | -38% | 2 |
| 7 (3) |  | Miami Vice () | £604,441 | £1,390,136 | £6,130,954 | -49% | 3 |
| 8 (6) |  | Kabhi Alvida Naa Kehna () | £306,411 | £690,647 | £1,439,890 | -59% | 2 |
| 9 (11) |  | Garfield 2 () | £296,520 | £709,875 | £4,742,570 | -6% | 5 |
| 10 (7) |  | The Break Up (2006) | £285,354 | £761,594 | £9,648,851 | -49% | 5 |
| 11 (new) |  | Harsh Times (2005) | £281,609 | £281,609 | £281,609 | new | 1 |
| 12 (new) |  | A Scanner Darkly (2006) | £242,990 | £242,990 | £242,990 | new | 1 |
| 13 (10) |  | Superman Returns () | £202,061 | £535,329 | £15,426,329 | -50% | 6 |
| 14 (8) |  | My Super Ex-Girlfriend () | £197,615 | £650,072 | £2,548,064 | -59% | 3 |
| 15 (12) |  | Stormbreaker () | £194,085 | £523,959 | £5,878,051 | -30% | 5 |
| 16 (re) |  | Deep Sea 3D (2006) | £20,217 | £20,217 | £1,031,662 | re | 14 |
| 17 (re) |  | Thank You For Smoking () | £10,497 | £10,497 | £1,482,099 | re | 9 |
| 18 (17) |  | Little Fish () | £9,881 | £26,907 | £287,163 | -60% | 5 |
| 19 (re) |  | Renaissance (2006) | £3,443 | £3,443 | £67,062 | re | 3 |
| 20 (16) |  | Warrior King () | £2,068 | £13,585 | £128,199 | -93% | 4 |