North American Number 1 movies in 2021
| Title | Weeks | ||
| 33. |  | Spider-Man: No Way Home (2021) | 3 |
| 32. |  | West Side Story (2021) | 1 |
| 31. |  | Encanto (2021) | 2 |
| 30. |  | Ghostbusters: Afterlife (2021) | 1 |
| 29. |  | Eternals (2021) | 2 |
| 28. |  | Dune (2021) | 2 |
| 27. |  | Halloween Kills (2021) | 1 |
| 26. |  | No Time To Die (2021) | 1 |
| 25. |  | Venom: Let There Be Carnage (2021) | 1 |
| 24. |  | Shang-Chi and the Legend of the Ten Rings (2021) | 4 |
| 23. |  | Candyman (2021) | 1 |
| 22. |  | Free Guy (2021) | 2 |
| 21. |  | The Suicide Squad (2021) | 1 |
| 20. |  | Jungle Cruise (2021) | 1 |
| 19. |  | Old (2021) | 1 |
| 18. |  | Space Jam: A New Legacy (2021) | 1 |
| 17. |  | Black Widow (2021) | 1 |
| 16. |  | Fast and Furious 9 (2021) | 2 |
| 15. |  | The Hitman's Wife's Bodyguard (2021) | 1 |
| 14. |  | A Quiet Place: Part II (2021) | 2 |
| 13. |  | The Conjuring: The Devil Made Me Do It (2021) | 1 |
| 12. |  | Spiral: From the Book of Saw (2021) | 2 |
| 11. |  | Wrath of Man (2021) | 1 |
| 10. |  | Demon Slayer The Movie: Mugen Train (2020) | 1 |
| 9. |  | Mortal Kombat (2021) | 1 |
| 8. |  | Godzilla Vs. Kong (2021) | 3 |
| 7. |  | Nobody (2021) | 1 |
| 6. |  | Raya and the Last Dragon (2021) | 3 |
| 5. |  | Tom & Jerry: The Movie (2021) | 1 |
| 4. |  | The Croods: A New Age (2020) | 2 |
| 3. |  | The Little Things (2021) | 2 |
| 2. |  | The Marksman (2021) | 2 |
| 1. |  | Wonder Woman 1984 (2020) | 2 |